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butabarbital will lessen the level or impact of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Outcome of coadministering a robust CYP3A4 inducer with fedratinib has not been examined.butabarbital will lessen the extent or result of midazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism